In order to improve the attention of 3-12-year-old children to oral health, popular science children and parents should understand and pay attention to the knowledge of odontogenic mesenchymal stem cells. On January 15, 2023, on the occasion of leaving the old year and welcoming the new year, the first parent-child event of "small dentist tooth cell treasure hunt" jointly organized by Sichuan cell bank and Xinqiao stomatology was held at Sichuan Cell Bank Co., Ltd., building E7, Frontier Medical Center. The staff of Sichuan cell bank company and the staff of Xinqiao oral marketing department and planning department jointly organized 13 groups of parent-child families to participate in this activity.
The "little dentist's tooth cell treasure hunt" activity is divided into seven links: novelty hunting in the tooth cell reserve room, secret exploration in the cell preparation room, experimental microscopic science, courage challenge in the oral experience room, honorary certificate issuance of little dentist and little scientist, gift exchange and group photo. During the first four steps of the activity, children will receive a customs clearance sticker after completing each step of the task. At the end of the activity, gifts will be changed according to all customs clearance stickers obtained.
The technician of the Sichuan Provincial cell bank gave an opening presentation to the parent-child family members who participated in the "little dentist's tooth cell treasure hunt", and introduced the concept, development, scientific research status, oral health and storage of dental stem cells to the children and parents in a popular and professional way, Let the children know that the mesenchymal stem cells that can be extracted from the dental tissue that turns waste into treasure are of great help to human health.
The first part of the "little dentist's tooth cell treasure hunt" activity is the curiosity of the tooth cell reserve room. The children and parents visited the Sichuan cell bank reserve room under the leadership of the cell bank technician. Professor Tang from the Sichuan cell bank systematically explained the storage scale of the Sichuan cell bank and the conditions, environment, equipment and operation of cell science storage, and interacted with the children, The children listened carefully to Professor Tang's lecture and watched the use and maintenance of cell storage devices by cell bank managers from a close distance.
The second part of the "little dentist's tooth cell treasure hunt" activity is to explore the secrets of the tooth cell preparation room. Under the guidance of the guide, the children and parents visited a 3500 square meter GMP standardized preparation workshop that meets the requirements of cell preparation process, introduced the whole process of cells from teeth to cell finished products, as well as the functions and functions of key equipment used in cell preparation, and visited the process of cell production and preparation being carried out by the cell preparer. The whole process made the children have a strong interest in the preparation of cells.
The third part of the "little dentist's tooth cell treasure hunt" activity is experimental microscopic science. The cell bank engineer shows the children the liquid nitrogen frozen live fish recovery experiment. Under the children's gaze, a live fish is put into liquid nitrogen at -180 degrees Celsius, and the fish changes from fresh to frozen and unable to move. Finally, after warm water recovery, the fish returns to fresh, The guide introduced the principle of cell cryopreservation and resuscitation to the children through the experimental phenomenon.
The open platform area of the cell detection laboratory has prepared a microscope for children to observe cells. Children and parents observe odontogenic stem cells and other cells and micro organisms through the microscope, so that children can observe the colorful micro world under the microscope and observe the real morphology of dental cells. The children actively participated in the activity experiment.
The fourth link of the "little dentist's tooth cell treasure hunt" activity is the courage challenge in the oral experience room. The dental teacher in charge of children's dental health in Xinqiao oral explained to the children the knowledge of dental fundamentals such as tooth growth and replacement, as well as the correct way of brushing teeth in the oral experience room. During the activity, the children worked in groups of two to act as dentists and guests respectively to have an interesting professional experience of little dentists.
At the end of the four activities, the Xinqiao dental teacher presented the children who completed the activity with the honorary certificate of child dentist and the honorary certificate of child scientist. At the same time, the children exchanged the desired gifts according to the number of stickers obtained by the activity.
At the end of the activity, the children took photos.
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Sichuan Provincial cell bank is a comprehensive cell bank and national cell resource bank established by the government, West China Hospital, West China Second Hospital women's and children's Hospital, West China stomatological hospital, together with the national "973" and national key R & D Program project scientists team, which focuses on cell storage and stem cell drug research and development. The storage area is 1000 square meters, and the design storage capacity is up to 10 million copies per person time. It has internationally leading core storage technology World class storage technology, the most advanced freezing equipment and fully automated storage management system.
Phase I has completed the construction of a 3500 square meter platform, including a national cell information resource bank (which can store cells for tens of millions of people), a regional cell preparation center in six independent cell GMP production workshops that meet the highest international standards (which can produce more than 10 kinds of adult stem cells, iPS cells and immune cells), and a cell quality testing center that meets third-party services (with more than 80 cell quality related tests), A quality system traceable from the whole cycle of cell preparation, detection and storage has been formed. It undertook the construction of the national adult stem cell resource bank and the national human genetic resource collection center (southwest Innovation Center) to expand the platform's regional innovation and service capabilities. Relying on the powerful research platform of West China, it includes two state key laboratories, national and local joint engineering laboratories, multiple Ministry of education and Sichuan Engineering Technology Research Center. Based on the research results of cell therapy in the fields of oral diseases, reproductive medicine, sports medicine, rheumatism and immunity, endocrine diseases, cardiovascular diseases and neonatal brain injury over the years, a multidisciplinary expert team in the field of stem cell and regenerative medicine is carrying out clinical research on stem cell drugs for periodontal disease and subacute spinal cord injury, striving to fill the gap of stem cell drugs in China, aiming to promote cell storage Research and development of cell drugs, clinical research of cell therapy, and transformation and application of innovative biological technologies. Accelerate the construction of "cell drug quality evaluation system, cell production standardization system, cell technology innovation system, cell clinical research service system", research and production double drive, become a leader in cell diagnosis and treatment, and a pioneer in cell drugs.
Cell storage type:
Umbilical cord mesenchymal stem cells, placenta mesenchymal stem cells, odontogenic stem cells (dental pulp stem cells, dental follicle stem cells, deciduous tooth stem cells, apical dental papilla stem cells), adipose stem cells, bone marrow stem cells, immune cells, neonatal immune cells
International leading core storage technology
Cell preparation:
Taking ISO9001, 1s014001 and 1so45001 as standards, and combining with AABB quality standard, GMP and the relevant guiding principles of the cell industry, a quality control system was established. A complete set of SOP and quality management system for cell operation was established around the collection, transportation, reception, culture, storage, detection and ex warehouse of raw materials. Each participating element was strictly controlled and managed to ensure cell quality and safety.
Cell freezing:
The thermofisher program cooling system of the United States can accurately control the temperature and ensure the quality of cells in the process of cell cooling.
Cell storage:
The cell bank adopts the thermofisher liquid nitrogen storage system of the United States, which can realize long-term stable storage of cells at -196 ° C.
World class storage technology
Storage process:
Sample receiving, comprehensive detection, cell separation, programmed cooling and low-temperature storage.
Receiving process:
Automatically record the temperature during sample transportation.
Detection process:
Sterility test, cell colony culture, immunological analysis, flow cytometry test, HLA subtype analysis, cell viability test.
Monitoring process:
24-hour real-time online monitoring of temperature, humidity, pressure, air flow, dust particles, personnel operation and low-temperature storage system.
Information system:
The data center records and stores all information of cell cryopreservation.
